Atividade antimalárica da kalanchoe pinnata sobre o plasmodium berghei em modelo experimental in vivo
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2019-02-20Autor
http://lattes.cnpq.br/8367112484814924
ALMEIDA, Arimar Chagas de
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Malaria is an infectious disease caused by a microscopic parasite, which infects about
200 million people a year. It presents as a cyclic fever followed by chills, intense
sweating, nausea, vomiting, pallor and physical weakness, which intensify according
to the level of parasitemia and the species of Plasmodium that infect individuals.
Despite being a worldwide problem, malaria does not present a homogeneous
geographic distribution, being its higher incidence in tropical and subtropical regions
such as the Legal Amazon in Brazil. Currently, a range of drugs used to treat malaria
has become inefficient because some strains of Plasmodium vivax and Plasmodium
falciparum already have developed multiple resistance to these drugs. In this context,
it is necessary to search for new therapeutic alternatives for the treatment of malaria,
such as plants. Among the thousands of plant species, Kalanchoe pinnata is a plant
that presents indicative of hypotensive, anti-inflammatory and antirheumatic effect.
Thus, the possibility of researches with the extract of Kalanchoe pinnata, widely used
in the North of Brazil for the treatment of inflammations, wounds, cutaneous ulcers,
abscesses, analgesia and also antiparasitic activity against Leishmania amazonensis.
In view of this, the present study aims to evaluate the antimalarial activity of the
hydroalcoholic extract of Kalanchoe pinnata in an in vivo model of malaria using
BALB/c mice infected with Plasmodium berghei. To this end, the hydroalcoholic extract
of Kalanchoe pinnata was evaluated for its toxicity and effects (suppression of parasite
density, animals survival time, plasma glucose levels, liver and renal function and
haematological parameters) in the treatment of BALB/c mice infected with Plasmodium
berghei. Thus, K. pinnata extract was safe for treatment with the studied doses,
showing similar effect of the standard drug artemisinin, such as increased survival time,
parasitic suppression, control of glycemic levels and renal and hepatological functions,
besides haematological parameters. Thus, it has been shown that this extract presents
itself as an effective alternative for the treatment of malaria, and further studies should
be performed to determine the stability of the formulation and clinical and regulatory
evaluations in order to achieve commercialization.
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