Atividade anti-inflamatória e antinociceptiva do óleo essencial de Cyperus articulatus var. nodosus L.
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2019-02-20Autor
PEREIRA, Andrew Mairom Nogueira
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The Cyperus articulatus var. nodosus L. (Priprioca) is a plant found in the Amazon region
due to the biodiversity of plant species in this place and has become important source in the
discovery of new drugs. Phytochemical studies carried out on essential oil have been
identified from terpene compounds. Based on the presence of the compounds present in
Cyperus articulatus var. nodosus L. grows the hypothesis of having anti-inflammatory and
antinociceptive activity. Phytochemical study on essential oil identified the presence of
terpene compounds. Considering the chemical compounds present in the essential oil of
Cyperus articulatus var. nodosus (OECA) and ethnopharmacological application, the
objective of the research was to evaluate the anti-inflammatory and antinociceptive activity of
the essential oil of Cyperus articulatus var. nodosus in experimental models of inflammation
and nociception in rats and mice. The botanical material was provided by the Research and
Development Laboratory of bioactive natural products of UFOPA, which was collected in
Tabocal region in the municipality of Santarém-PA, identified by Dr. Antônio Elielson Sousa
da Rocha. The chemical characterization of the sample was carried out at the
multidisciplinary center for chemical, biological and agricultural research of UNICAMP-SP.
The assessment of acute oral toxicity was assessed according to OECD protocol 423/2001.
The antinociceptive activity has followed the protocols of the Hot Plate, Abdominal
Contortion and Formalin tests. The anti-inflammatory activity was evaluated with the Airbag
and Evanz Blue tests. The chemical composition analysis indicated the presence of
monoterpenes, sesquiterpenes and sesquiterpene ketones as major constituents of OECA. The
safe dose is less than 2,000 mg / kg administered orally. It presents antinociceptive activity
increasing the pain threshold induced by chemical substances (acetic acid and formalin) and
thermal stimulation. Anti-inflammatory activity is observed, decreasing the exudate volume at
the inflamed site as a consequence of the decrease in vascular permeability observed in the air
bag and Evanz Blue test. The anti-inflammatory effect was also observed in the reduction of
leukocyte migration in the air bag test. From the results obtained, we conclude that the
essential oil of Cyperus articulatus L. var. nodosus, consists mainly of sesquiterpenes and
monoterpenes. The safe dose is less than 2,000 mg / kg administered orally. OECA has
antinociceptive activity increasing the pain threshold induced by chemical substances (acetic
acid and formalin) and thermal stimulation. It presented anti-inflammatory activity,
decreasing the exudate volume at the inflamed site as a consequence of the decrease in
vascular permeability observed in the air bag and Evanz Blue test. The anti-inflammatory
effect was also observed in the decrease of leukocyte migration in the air bag test.
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