Efeitos da carboxiterapia na cicatrização de feridas cutâneas em ratos
Fecha
2019-07-26Autor
http://lattes.cnpq.br/6997562015741686
FERREIRA, Brenno de Sousa
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This study aimed to evaluate the effects of carboxytherapy, infusion in the subcutaneous
tissue of medicinal CO2, in the healing of cutaneous lesions in Wistars rats. This is an
experimental and quantitative study, with a sample of 10 animals divided into a control group
and a carboxytherapy group. All animals suffered a metallic punch injury of 5mm diameter
in the dorsal region and the group with therapy treated for 10 consecutive days and then
euthanized on the 11th day of the experiment. The region was photographed at various
moments of the research to analyze the morphometric evolution of the lesion area and tissue
samples containing the lesion were removed for microscopic analysis. . Histological analysis
consisted of checking for collagen deposition, proliferation of fibroblasts and new blood
vessels. The morphometric results showed that there was no increase in the velocity of
closure of the lesion area. The carboxytherapy group presented higher total collagen
deposition, type I and type III, and a greater proliferation of fibroblasts compared to the
control group, but non-statistically significant data. The evaluation of the formation of new
blood vessels had a positive result, with statistically significant numbers (p <0.05). At the
end of this research, it was concluded that carboxitherapy may be a good treatment option
for cutaneous wounds, especially in lesions with scarring due to microcirculatory deficit.
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