Avaliação da atividade farmacológica in vivo do óleo essencial da Piper marginatum (Piperacea)

Abstract

Piper margintum, in the Piperacea family is a native and endemic plant in Brazil. It is an important plant used medicinally in South and Central America. The most common use of Piper marginatum is related to gastrointestinal diseases. The aim of this study was to evaluate the possible gastroprotective and antiedematogenic effects of Piper marginatum Essential Oil. For antiedematogenic effect was used the ear edema induced by Phenol. For the gastroprotective effect was used the gastric injury induced by acified ethanol and Indomethacin. It was observed after 1 hour of edema induction, the OEPM inhibited edema both at the dose of 1000 mg / kg (55%) and 500 mg / kg (42%) when compared to the Phenol group. In the acidified acid-induced gastric injury test, the OEPM showed a lower percentage of ulcerated area at the doses of 1000mg / kg (7.90%) and 500 mg / kg (8.41%), when compared to the control group (17.92%). In the indomethacin-induced gastric test, a lower percentage of ulcerated area was observed in the groups which received the OEPM; however, there was no statistically significant difference at 1000 (9.02%), 500 (11.61%) and 250 mg / kg (15.08%), when compared to the control group (16.92%). The results presented in this study showed the OEPM has active compounds with gastroprotective and antiedematogenic effects.